Event date: 2 June 2018 23:59
Location: University of Cambridge
Department of Veterinary Medicine, University of Cambridge, 20/08 – 7/09/2018
Two enthusiastic students have the opportunity to work on a 3 weeks long scientific project in the field of microbial metagenomics at the Department of Veterinary Medicine, University of Cambridge. In the Bacterial Infection Group researchers are working on the detection and tracking of antimicrobial resistance genes. The two candidates will characterise inter-species genomic repeat elements, those variable length sequence elements that cause significant problems during the computerised metagenomics pipelines. The majority of the work will be bioinformatics based, manipulation of large sequence sets on high-performance computers, but the candidates will also understand and learn the microbiology behind the subject and the laboratory techniques preceding the data analysis. The final aim of the project is to build up a comprehensive dataset of sequences (and species bindings) on these repeat sequences. The candidates have to have a strong interest in biology and the ability to work on computers (ideally with basic knowledge on Linux command line, and programming). The main learning outcomes are: (i) obtaining general knowledge on microbial metagenomics, Linux computer environment, and Perl programming language; (ii) handle and analyse next-generation sequencing data and large DNA sequence datasets; (iii) discuss and review the scientific work while working in a team (the two candidates will work together); (iv) prepare and incorporate computer programs into existing pipelines. The candidates will work in the research group led by Dr Mark Holmes and Dr Andrew Grant, under the direct supervision of a senior postdoctoral scientist, Dr Lajos Kalmar. Students have to be prepared for fund their travel and accommodation costs, however, some support from the research group is under arrangement.